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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Predictive Toxicology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1421437

Treatment of an accident of imidacloprid poisoning

Provisionally accepted
Mei Zeng Mei Zeng 1Mengdi Shi Mengdi Shi 2Xiangdong Jian Xiangdong Jian 1Laidong Dong Laidong Dong 3*
  • 1 Department of Poisoning and Occupational Diseases, Qilu Hospital, Shandong University, Jinan, China
  • 2 Department of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Jinan, Shandong Province, China
  • 3 Department of Outpatient, Qilu Hospital, Cheeloo College of Medicine, Shandong University, jinan, China

The final, formatted version of the article will be published soon.

    Objective: Accidental oral imidacloprid poisoning occurred in a family in Shandong, China, in May 2023. This study aimed to analyze the clinical characteristics of this imidacloprid poisoning event and investigated the detection of toxicants. Methods: Clinical data of four patients with oral imidacloprid poisoning were collected and retrospectively analyzed. The relevant literature was then reviewed. Results: Four patients from the same family received different oral doses of imidacloprid. The main clinical manifestations were digestive and neurological symptoms, including nausea, vomiting, and varying degrees of consciousness. Laboratory tests showed an increased white blood cell count, neutrophil proportion, and mild elevation of transaminase and urea nitrogen levels in some patients. Following comprehensive treatment, which included hemoperfusion, gastric lavage, total gastrointestinal decontamination, and drug symptomatic treatment, the patient's symptoms were quickly relieved, and the concentration of imidacloprid in the blood rapidly decreased. Conclusion: Toxicant detection is an important criterion for the differential diagnosis of poisoning and is helpful for disease assessment, treatment plan formulation, and in determining patient prognosis. Comprehensive treatment is an effective therapy for oral imidacloprid poisoning.

    Keywords: imidacloprid, Acute poisoning, toxicant detection, Hemoperfusion, case report

    Received: 29 Apr 2024; Accepted: 02 Jul 2024.

    Copyright: © 2024 Zeng, Shi, Jian and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Laidong Dong, Department of Outpatient, Qilu Hospital, Cheeloo College of Medicine, Shandong University, jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.