This article is a correction to:
A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth
Uttara Saran1†
Balaji Chandrasekaran1†
Ashish Tyagi1
Vaibhav Shukla1
Amandeep Singh2Arun K. Sharma2Chendil Damodaran1*- 1Texas A&M University, College Station, United States
- 2Penn State Cancer Institute, College of Medicine, The Pennsylvania State University, Hershey, PA, United States
A Corrigendum on
A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth
by Saran U, Chandrasekaran B, Tyagi A, Shukla V, Singh A, Sharma AK and Damodaran C (2023). Front. Pharmacol. 14:1150774. doi: 10.3389/fphar.2023.1150774
In the published article, there was an error in Figure 9 as published. Specifically, in Figure 9D, the same image was repeated for both ALDH- HES1 (Veh) and ALDH + Ki67 (ASR490). The correct IHC image for ALDH- HES1 (Veh) has been updated. The corrected Figure 9 and its caption appear below.
Figure 9
Figure 9. ASR490 reduces the tumor burden of xenotransplanted breast tumors. (A) Oral administration of ASR490 (25 mg/kg) significantly inhibited the growth of ALDH− and ALDH+ xenotransplanted tumors (n = 6, *p < 0.01, ***p < 0.001). (B) Tumor weight of vehicle and ASR490 treated ALDH− and ALDH+ tumors. (C) Western blots performed for Notch1-NICD and HES1 on vehicle and ASR490-treated ALDH− and ALDH+ tumors. (D) IHC analyses was performed on vehicle and ASR490-treated ALDH− and ALDH+ tumors to evaluate the expressions of Notch1-NICD, HES1, and Ki67 (proliferation marker). p values were calculated using a two-sided Student’s t-test.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: breast cancer, breast cancer stem cell (BCSC), ASR490, autophagy, NOTCH1
Citation: Saran U, Chandrasekaran B, Tyagi A, Shukla V, Singh A, Sharma AK and Damodaran C (2024) Corrigendum: A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth. Front. Pharmacol. 15:1420266. doi: 10.3389/fphar.2024.1420266
Received: 19 April 2024; Accepted: 06 May 2024;
Published: 27 May 2024.
Edited and reviewed by:
Eswar Shankar, The Ohio State University, United StatesCopyright © 2024 Saran, Chandrasekaran, Tyagi, Shukla, Singh, Sharma and Damodaran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Chendil Damodaran, Y2hlbmRhbW9kYXJAZXhjaGFuZ2UudGFtdS5lZHU=
†These authors have contributed equally to this work