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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1414635

Alpinia officinarum Hance: a comprehensive review of traditional uses, phytochemistry, pharmacokinetic and pharmacology

Provisionally accepted
Lei Xia Lei Xia 1Jiapeng Wang Jiapeng Wang 1Kun Zuo Kun Zuo 1Tianli Xia Tianli Xia 1Jinfeng Zhang Jinfeng Zhang 1Xiangyue Xu Xiangyue Xu 1Qing Liu Qing Liu 1Xiaoliang Li Xiaoliang Li 2*
  • 1 Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, wuxi, China
  • 2 Hainan Medical University, Haikou, China

The final, formatted version of the article will be published soon.

    The dried root and rhizome of Alpinia officinarum Hance (A. officinarum) have been widely used in traditional Chinese medicine for thousands of years to alleviate pain, promote digestion, warm the stomach, and disperse cold. This review aims to comprehensively and in-depth summarize the most recent research on the traditional uses, phytochemistry, pharmacokinetics, and pharmacology of A. officinarum. By searching various databases including Web of Science, PubMed, Google Scholar, Elsevier, Springer, ScienceDirect, and China National Knowledge Infrastructure (CNKI) for literature on "Alpinia officinarum Hance", as well as relevant textbooks and digital documents, an overall and critical review of the subject was conducted. The traditional uses of A. officinarum were summarized, and 337 compounds from A. officinarum were summarized, including flavonoids, diarylheptanoids, volatile oils, and other compounds. Studies have found that the crude extract of A. officinarum and its compounds has a wide range of biological activities, such as improving gastrointestinal function, anti-inflammatory properties, anti-tumor activity, antibacterial properties, memory enhancement, and analgesic effects. Modern pharmacological studies have provided strong evidence and explanations for the traditional medicinal uses of A. officinarum, which brings a broad prospect for its medicinal use. However, more research is needed to explore the structure-activity relationship and potential mechanisms of action of its bioactive chemicals. Furthermore, it is essential to conduct more clinical trials in order to accelerate research and 2 development of the drug.

    Keywords: Alpinia officinarum hance, Traditional uses, phytochemistry, Pharmacology, pharmacokinetic 1.Introduction

    Received: 09 Apr 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Xia, Wang, Zuo, Xia, Zhang, Xu, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaoliang Li, Hainan Medical University, Haikou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.