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REVIEW article

Front. Pharmacol.
Sec. Translational Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1412672

New insights into the roles of lactylation in cancer

Provisionally accepted
Yajun Zhu Yajun Zhu Wenhui Liu Wenhui Liu Zhiying Luo Zhiying Luo Feiyan Xiao Feiyan Xiao Bao Sun Bao Sun *
  • Second Xiangya Hospital, Central South University, Changsha, China

The final, formatted version of the article will be published soon.

    Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and nonhistone proteins. Recent studies have confirmed that lactylation as a new contributor to epigenetic landscape is involved in multiple pathological processes. Accumulating evidence reveals that lactylation exists in different pathophysiological states and leads to cancer, inflammation and cancerneuropsychiatric disorders; however, few mechanisms of lactylation have been elaborated. This review summarizes the biological processes and pathophysiological roles of lactylation in cancer, as well as discusses the relevant mechanisms and potential therapeutic targets, aiming to provide new insights for targeted cancer therapy.

    Keywords: lactylation, Lactate, histone and nonhistone proteins, Cancer, therapeutic targets

    Received: 05 Apr 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Zhu, Liu, Luo, Xiao and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bao Sun, Second Xiangya Hospital, Central South University, Changsha, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.