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BRIEF RESEARCH REPORT article

Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1407228
This article is part of the Research Topic Advances in Drug-induced Diseases Volume II View all 21 articles

ICMR -National Institute of Cholera and Enteric Diseases

Provisionally accepted
Sohini Sikdar Sohini Sikdar Debmalya Mitra Debmalya Mitra Oishika Das Oishika Das Moumita Bhaumik Moumita Bhaumik *Shanta Dutta Shanta Dutta
  • National Institute of Cholera and Enteric Diseases (ICMR), Kolkata, India

The final, formatted version of the article will be published soon.

    Pharmacology as a brief report. On behalf of coauthors, I declare this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere.We have no conflicts of interest to disclose. FTY720 or Fingolimod is a drug commonly used in the treatment of Multiple Sclerosis. In this brief report we show that FTY720 treatment in mice can cause impairs barrier function by affecting the tight junction protein expression in gut and thereby leading to gut inflammation.We believe, this is an important observation as a vigilance on gut inflammation should be maintained in the patients receiving this drug for autoimmune disorders.

    Keywords: FTY720, Sphingosine1 phosphate, Occludin, Claudin-4, Gut permeability

    Received: 26 Mar 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Sikdar, Mitra, Das, Bhaumik and Dutta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Moumita Bhaumik, National Institute of Cholera and Enteric Diseases (ICMR), Kolkata, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.