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REVIEW article

Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1406510
This article is part of the Research Topic Reviews in Cardiovascular Pharmacology: 2023 View all 12 articles

Amentoflavone for treating cardiocerebrovascular diseases and neurological disorders

Provisionally accepted
Hang Zhang Hang Zhang Yin-Mei Ban Yin-Mei Ban De-Mei Li De-Mei Li Gang Wang Gang Wang Juan Gu Juan Gu Lei Zhu Lei Zhu *
  • Zunyi Medical University, Zunyi, Guizhou Province, China

The final, formatted version of the article will be published soon.

    Amentoflavone (AME) is a flavonoid compound found in over 120 plants. Its extensive pharmacological activity for treating cardiocerebrovascular diseases and neurological disorders have attracted the attention of researchers in recent years.However, owing to the poor solubility and low bioavailability of AME, it has not been developed as a drug for treating these diseases. This review focuses on two aspects of AME: First, it provides a detailed summary and introduction to AME based on its chemical structure, physicochemical properties, plant sources, extraction and purification methods, administration systems, and pharmacokinetic properties. Second, it summarizes the effects of AME on cardiocerebrovascular diseases and neurological disorders, and its specific pharmacological mechanisms. This review aims to promote the use of AME for treating cardiocerebrovascular diseases and neurological disorders. AME exhibits multiple activities, indicating its potential as a natural drug for treating these diseases. Further studies on its pharmacokinetics and toxicology are required to ensure its safety and efficacy.

    Keywords: Amentoflavone, Cardiovascular Diseases, cerebrovascular diseases, Neurological Diseases, Pharmacological effects, Anti-Inflammatory Agents, Chinese herbal medicine

    Received: 25 Mar 2024; Accepted: 07 Nov 2024.

    Copyright: © 2024 Zhang, Ban, Li, Wang, Gu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lei Zhu, Zunyi Medical University, Zunyi, 563000, Guizhou Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.