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BRIEF RESEARCH REPORT article

Front. Pharmacol.
Sec. Neuropharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1406238

Interplay between metabotropic Glutatmate type 4 and Adenosine type 1 Receptors Modulate Synaptic Transmission in the Cerebellar Cortex

Provisionally accepted
  • 1 Department of Physiology, Anatomy and Genetics, Medical Sciences Division, University of Oxford, Oxford, England, United Kingdom
  • 2 UMR9197 Institut des Neurosciences Paris Saclay (Neuro-PSI), Gif-sur-Yvette, Île-de-France, France

The final, formatted version of the article will be published soon.

    The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1) receptors both of which curtail glutamate release upon activation. Despite their pivotal role in regulating synaptic transmission within the cerebellar cortex, functional interactions between mGlu4 and A1 receptors have remained relatively unexplored. To bridge this gap, our study delves into how mGlu4 receptor activity influences A1 receptor-mediated alterations in excitatory transmission. Employing a combination of whole-cell patch clamp recordings of Purkinje cells and parallel fiber presynaptic fluorometric calcium measurements in acute rat and mouse cerebellar cortical slices, our results reveal functional interactions between these receptor types. These findings hold implications for understanding potential roles of these presynaptic receptors in neuroprotection during pathophysiological conditions characterized by elevated glutamate and adenosine levels.

    Keywords: Cerebellum, mGlu4 receptor, adenosine type-1 receptor, Interaction, neurotransmission

    Received: 24 Mar 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Bossi, Daniel and McLean. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Simon Bossi, Department of Physiology, Anatomy and Genetics, Medical Sciences Division, University of Oxford, Oxford, OX1 3PT, England, United Kingdom
    Heather McLean, UMR9197 Institut des Neurosciences Paris Saclay (Neuro-PSI), Gif-sur-Yvette, 91198, Île-de-France, France

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.