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MINI REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1404172
The possible anti-tumor actions and mechanisms of active metabolites from Cortex Fraxini
Provisionally accepted- 1 Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, Liaoning Province, China
- 2 Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, China
Cortex Fraxini is a traditional Chinese herb that is widely available, inexpensive, and has low toxicity. Modern pharmacological studies have demonstrated that the active metabolites in Cortex Fraxini, including esculin, esculetin, and fraxetin, exert antitumor activities by regulating genes and proteins involved in cancer cell proliferation, apoptosis, invasion, and migration. Additionally, these metabolites play a pivotal role in the regulation of several tumor-associated signaling pathways, including the PI3K/Akt, MAPK/ERK, JAK/STAT3, and Wnt/β-catenin pathways. Due to their proapoptotic and anti-proliferative properties in vitro and in vivo, Cortex Fraxini and its active metabolites may be considered as potential candidates for the treatment of tumor.The aim of this review is to highlight the anti-tumor biological activities and underlying mechanisms of action of the active metabolites of Cortex Fraxini, with a view to providing a reference for their further development and application in the treatment of tumors.
Keywords: Cortex Fraxini, anti-tumor, Esculin, esculetin, Fraxetin
Received: 20 Mar 2024; Accepted: 02 Sep 2024.
Copyright: © 2024 Cai, Cai, Feng and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ting Cai, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, 211166, Jiangsu Province, China
Huanhuan Zhu, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, Liaoning Province, China
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