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CASE REPORT article

Front. Pharmacol.
Sec. Pharmacogenetics and Pharmacogenomics
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1403390
This article is part of the Research Topic Advances in Pharmacogenomics: Basic, Translational, and Clinical View all 4 articles

Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS) induced by ceftazidime in a connective tissue disease (CTD) patient

Provisionally accepted
Rui Dai Rui Dai 1,2Ziran Niu Ziran Niu 1*Yang Yang Yang Yang 1Xin Liu Xin Liu 1*Bo Zhang Bo Zhang 1*
  • 1 Department of Pharmacy, Peking Union Medical College Hospital (CAMS), Beijing, Beijing Municipality, China
  • 2 Clinical Pharmacology Research Center, Peking Union Medical College Hospital (CAMS), Beijing, China

The final, formatted version of the article will be published soon.

    Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and severe cutaneous adverse drug reactions (SCARs) with high mortality. Antibiotics are the most frequent causative agents related to DRESS. However, it is rarely reported in cephalosporins, especially for ceftazidime. Here, we reported a case of ceftazidime-induced DRESS with HLA genotypic polymorphism as a risk factor. A 58-year-old woman with connective tissue disease was intravenously infused with ceftazidime for the treatment of pneumonia and intestinal infection, followed by the presence of fever, rash, and hematologic and hepatic laboratory abnormalities. DRESS was diagnosed and the positive polymorphism in HLA-B*15:02 was found. Our case illustrated the necessity to clarify the patho-mechanism and the use of pretreatment HLA analysis to prevent ceftazidime-related DRESS may be a valuable option soon.

    Keywords: DRESS (drug reaction with eosinophilia and systemic symptoms), Ceftazidime, CTD, HLA-B*15:02, case report

    Received: 19 Mar 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Dai, Niu, Yang, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ziran Niu, Department of Pharmacy, Peking Union Medical College Hospital (CAMS), Beijing, 100730, Beijing Municipality, China
    Xin Liu, Department of Pharmacy, Peking Union Medical College Hospital (CAMS), Beijing, 100730, Beijing Municipality, China
    Bo Zhang, Department of Pharmacy, Peking Union Medical College Hospital (CAMS), Beijing, 100730, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.