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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1402386
This article is part of the Research Topic Use of Bioactives for Treatment of Respiratory Diseases View all 8 articles

Aspirin reduces the mortality risk of patients with community-acquired pneumonia: A retrospective Propensity-Matched analysis of the MIMIC-IV database

Provisionally accepted
Guangdong Wang Guangdong Wang 1Jiaolin Sun Jiaolin Sun 2*Yaxin Zhang Yaxin Zhang 3*Na Wang Na Wang 1*Liu Tingting Liu Tingting 1Wenwen Ji Wenwen Ji 1Lin Lv Lin Lv 1*Xiaohui Yu Xiaohui Yu 1Xue Cheng Xue Cheng 1Mengchong Li Mengchong Li 1*Tinghua Hu Tinghua Hu 1*ZHIHONG SHI ZHIHONG SHI 1*
  • 1 Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
  • 2 Department of Respiratory and Critical Care Medicine, Shanxi Provincial People’s Hospital, xian, China
  • 3 Department of Neurology, Fujian Medical University Affiliated Xiamen Hong ′ai Hospital, xiamen, China

The final, formatted version of the article will be published soon.

    Background: Community-acquired pneumonia (CAP) is a common infectious disease characterized by inflammation of the lung parenchyma in individuals who have not recently been hospitalized. It remains a significant cause of morbidity and mortality worldwide. Aspirin is a widely used drug, often administered to CAP patients.However, the benefits of aspirin remain controversial.Objective: We sought to determine whether aspirin treatment has a protective effect on the outcomes of CAP patients.: We selected patients with CAP from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Propensity score matching (PSM) balanced baseline differences. A multivariate Cox regression model assessed the relationship between aspirin treatment and 28-day mortality.Results: A total of 3,595 patients were included, with 2,261 receiving aspirin and 1,334 not. After PSM, 1,219 pairs were matched. The 28-day mortality rate for aspirin users was 20.46%, lower than non-users. Multivariate Cox regression indicated aspirin use was associated with decreased 28-day mortality (HR 0.75, 95% CI 0.63-0.88, p < 0.001). No significant differences were found between 325 mg/day and 81 mg/day aspirin treatments in terms of 28-day mortality, hospital mortality, 90-day mortality, gastrointestinal hemorrhage, and thrombocytopenia. However, intensive care unit (ICU) stay was longer for the 325 mg/day group compared to the 81 mg/day group (4.22 vs. 3.57 days, p = 0.031).Aspirin is associated with reduced 28-day mortality in CAP patients.However, 325 mg/day aspirin does not provide extra benefits over 81 mg/day and may lead to longer ICU stays.

    Keywords: Community-acquired pneumonia, Intensive Care Unit, Aspirin, MIMIC-IV database, Mortality

    Received: 17 Mar 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Wang, Sun, Zhang, Wang, Tingting, Ji, Lv, Yu, Cheng, Li, Hu and SHI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiaolin Sun, Department of Respiratory and Critical Care Medicine, Shanxi Provincial People’s Hospital, xian, China
    Yaxin Zhang, Department of Neurology, Fujian Medical University Affiliated Xiamen Hong ′ai Hospital, xiamen, China
    Na Wang, Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
    Lin Lv, Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
    Mengchong Li, Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
    Tinghua Hu, Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
    ZHIHONG SHI, Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

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