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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1401594

Hyaluronic Acid-Solid Lipid Nano Transporter Serum preparation for Enhancing Topical Tretinoin Delivery: Skin safety study and Visual assessment of skin

Provisionally accepted
Yasir Mehmood Yasir Mehmood 1*Hira Shahid Hira Shahid 2Syeda Momena Rizvi Syeda Momena Rizvi 3Usama Jamshaid Usama Jamshaid 4Numera Arshad Numera Arshad 5Mohsin Kazi Mohsin Kazi 6*
  • 1 Riphah International University, Faisalabad Campus, Faisalabad, Punjab, Pakistan
  • 2 Government College University, Faisalabad, Faisalabad, Punjab, Pakistan
  • 3 Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad, Faisalabad, Punjab, Pakistan
  • 4 University of Central Punjab, Lahore, Punjab, Pakistan
  • 5 Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Punjab, Pakistan
  • 6 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    The use of nanosized particles is becoming more popular for the topical treatment of skin conditions. In this research work, we created and investigated the effects of solid lipid nanoparticles (SLN) containing hyaluronic acid and tretinoin. Solvent emulsification diffusion method was used to prepare the SLN formulation and characterized for their physicochemical properties. Fourier transform infrared spectroscopy was used to confirm that hyaluronic acid and tretinoin were incorporated in the SLN. Furthermore, X-ray diffractogram, thermal analysis including DSC and TGA and in vitro dissolution, permeation tests were also performed along with microbial assessment. Clinical studies in human were performed to evaluate the effect of the SLN on skin wrinkles. The SLN was 750 ±31.29 nm in size, with a zeta potential of 13.07 ± 0.75 mV and a narrow polydispersity index of 0.24 ± 0.12. The entrapment efficiency of tretinoin was found to be 90.07 ± 4.79%. Clinical studies in healthy human volunteers demonstrated that 90% of the tested individuals had improved skin conditions (reduction in wrinkles), by at least one grade after 4 weeks of treatment.Regarding the development on SLN, it was found that the internal phase concentration did not considerably affect the physicochemical and microbiological properties. Therefore, Hyaluronic acid has potential for the development of SLN applicable to cosmetic formulations, especially for skin.These findings show that the developed SLN have potential for use as cosmetics in the future.

    Keywords: Hyaluronic Acid, FILLER, Topical, Solvent, Diffusion, Tretinoin

    Received: 15 Mar 2024; Accepted: 29 Aug 2024.

    Copyright: © 2024 Mehmood, Shahid, Rizvi, Jamshaid, Arshad and Kazi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yasir Mehmood, Riphah International University, Faisalabad Campus, Faisalabad, Punjab, Pakistan
    Mohsin Kazi, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.