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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1401335

Appropriateness and Inappropriate Medication Predictors of Stress Ulcer Prophylaxis in the Intensive Care Unit

Provisionally accepted
Pan Zhang Pan Zhang 1*Siyang Wang Siyang Wang 2Tingting Zhi Tingting Zhi 2Naobei Ye Naobei Ye 1Haonan Sun Haonan Sun 1Xingyu Qin Xingyu Qin 1Shuhan Xu Shuhan Xu 1Ruiqin Zhang Ruiqin Zhang 2*
  • 1 Shanxi Medical University, Taiyuan, China
  • 2 Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China

The final, formatted version of the article will be published soon.

    Preventive drugs for stress ulcers are widely and unreasonably used in the Intensive Care Unit (ICU). This study aims to examine the appropriate utilization of medications for stress ulcer prophylaxis (SUP) and identify factors that contribute to the inappropriate use of these medications in the ICU of the Second Hospital of Shanxi Medical University. Methods: Patient cases admitted to the ICU during the period from May 2022 to May 2023 were extracted from the hospital's information management system. Single-factor analysis and multivariate logistic regression model analysis were performed using the SPSS to identify factors associated with inappropriate medication for prophylaxis. The efficacy of this predictive model was assessed through the use of the Receiver Operating Characteristic Curve (ROC) , while the Hosmer test was utilized to evaluate the model fit. Results: This study included a total of 651 patient cases that met the inclusion criteria.Among these cases, 48.39% were found to have received inappropriate medication of SUP. The analysis revealed a significant association between inappropriate medication and partial transfer to departments (P＜0.05), as well as the use of anticoagulants (P=0.009) in the prophylaxis group. In the non-prophylaxis group, the multifactorial logistic analysis indicated a significant correlation between inadequate prescriptions and partial transfer to departments (P＜0.05), as well as the presence of artificial airways (P＜0.01). Conclusion: There is a notable prevalence of inappropriate SUP in the ICU of this

    Keywords: Stress ulcer prophylaxis, Intensive Care Unit, Rational drug use, Proton Pump Inhibitors, operating characteristic curve

    Received: 19 Mar 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Zhang, Wang, Zhi, Ye, Sun, Qin, Xu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Pan Zhang, Shanxi Medical University, Taiyuan, China
    Ruiqin Zhang, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.