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REVIEW article

Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1399850

Regulation mechanism of microRNAs in cardiac cells-derived exosomes in cell crosstalk

Provisionally accepted
Shanshan Lin Shanshan Lin 1,2*Yuanjian Yang Yuanjian Yang 3Zhou Zhou Zhou Zhou 1,2Wen Li Wen Li 1,2Xianliang Wang Xianliang Wang 1YU LIU YU LIU 1Yingfei Bi Yingfei Bi 1Jingyuan Mao Jingyuan Mao 1*
  • 1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin, China
  • 2 Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • 3 Affiliated Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    The heart is a multicellular system, and the intercellular crosstalk mechanism is very important for the growth and development of the heart and even the organs, tissues, and cells at a distance. As a kind of extracellular vesicle, exosomes are released by different types of cells and can carry specific genetic material, endosomal proteins, cytokines, etc., which are the main material basis for mediating cell crosstalk mechanism. Among them, microRNA carried by cardiac cells-derived exosomes have highly conserved sequences and play a key role in regulating the function of organs, tissues, and cells related to cardiovascular diseases and their complications and comorbidities, which have attracted extensive attention in the medical community in recent years. Following up on the latest research progress at home and abroad, this review systematically summarized the regulatory role of microRNA from cardiac cells-derived exosomes in various cell crosstalk, including not only cardiac cells (including cardiomyocytes, fibroblasts, myofibroblast, cardiac progenitor cells, cardiac microvascular endothelial cells, cardiosphere-derived cells, etc.) but also tumor cells, bone marrow progenitor cells, and other tissue cells, in order to provide a reference for the prevention and treatment of cardiovascular diseases and their complications and comorbidities.

    Keywords: cardiac cells-derived exosome, microRNA, Cell crosstalk, Mechanism research, review

    Received: 12 Mar 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Lin, Yang, Zhou, Li, Wang, LIU, Bi and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shanshan Lin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, 300193, Tianjin, China
    Jingyuan Mao, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, 300193, Tianjin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.