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REVIEW article

Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1399573

The role of extracellular vesicles in liver fibrosis: novel diagnostic and therapeutical opportunities of migrasomes?

Provisionally accepted
Xiang Tao Xiang Tao 1*Can Chen Can Chen 2Mei Liu Mei Liu 1
  • 1 Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • 2 Clinical Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

The final, formatted version of the article will be published soon.

    Extracellular vesicles (EVs) are membrane-enclosed particles that are secreted by various types of cells, including exosomes, microvesicles, apoptotic vesicles and newly discovered migrasomes.They can be taken up by recipient cells and modulate their function by transporting cargo molecules. EVs facilitate intercellular communication and participate in various physiological and pathological processes. Furthermore, the detection of EVs in different body fluids can provide sensitive diagnostic tools for various liver diseases. In addition, EVs can serve as therapeutic targets, potential therapeutic agents and drug delivery vehicles. This article reviews the recent advances in the field of EVs in liver fibrosis and related diseases, focusing on the potential role of newly discovered EVs migrasomes in intracellular crosstalk involving the liver.

    Keywords: extracellular vesicles, liver fibrosis, migrasomes, Exosomes, trestment, diagnostics

    Received: 12 Mar 2024; Accepted: 25 Jun 2024.

    Copyright: © 2024 Tao, Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiang Tao, Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.