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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1399177

Treatment satisfaction and medication adherence and predictors among patients with heart failure in Ethiopia: A hospital-based cross-sectional study

Provisionally accepted
Abate W. Tsige Abate W. Tsige 1*Bedilu Endalifer Bedilu Endalifer 1Habtemariam Alekaw Habteweld Habtemariam Alekaw Habteweld 1*Yehualashet Wondmkun Yehualashet Wondmkun 1Siraye G. Ayele Siraye G. Ayele 2Belayneh Kefale Belayneh Kefale 3
  • 1 Debre Berhan University, Debre Berhan, Ethiopia
  • 2 Addis Ababa University, Addis Ababa, Addis Ababa, Ethiopia
  • 3 Bahir Dar University, Bahir Dar, Amhara Region, Ethiopia

The final, formatted version of the article will be published soon.

    Background: Globally, about 18 million people died from cardiovascular diseases (CVDs) in 2019, over three-quarters in developing countries. Non-adherence to medication in CVD patients causes hospitalization, worsened symptoms, higher healthcare costs, and more emergency visits. Hence, this study aimed to assess treatment satisfaction and medication adherence and predictors in heart failure (HF) patients attending Debre Berhan Comprehensive Specialized Hospital (DBCSH), Ethiopia.Methods: A hospital-based cross-sectional study was undertaken at the medical referral clinic of DBCSH. A total of 344 ambulatory HF patients who visited the medical care of the DBCSH medical referral clinic during the study period were included. Treatment satisfaction was assessed using a self-administered Medicine Questionnaire (SATMED-Q). Relationships between predictor variables and treatment satisfaction were determined using one-way analysis of variance (ANOVA) and an independent t-test. Medication adherence was determined using the Morisky Green Levin Medication Adherence Scale (MGLS).Results: Participants with drug-drug interactions (DDIs) were approximately 38% less likely to adhere to medication compared to their counterparts (AOR = 0.62, 95% CI: 0.54-0.71). Additionally, participants who had taken five or more drugs were approximately 68% less likely to adhere to medication compared to those who had taken only one drug (AOR = 0.32, 95% CI: 0.2-0.51). The correlation between medication adherence and drug-drug interactions remains a possible pseudo-correlation via the number of medications taken. There was a noteworthy positive correlation (rs = 0.34, p = 0.027) between participants' treatment adherence and treatment satisfaction.The rate of treatment satisfaction and treatment adherence among HF patients was 67.6% and 60.9%, respectively. The presence of DDI and the number of drugs were identified as predictors to medication adherence.

    Keywords: Treatment satisfaction, Medication Adherence, Heart Failure, Ethiopia, Debre Berhan Comprehensive Specialized Hospital

    Received: 13 Mar 2024; Accepted: 02 Jul 2024.

    Copyright: © 2024 Tsige, Endalifer, Habteweld, Wondmkun, Ayele and Kefale. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Abate W. Tsige, Debre Berhan University, Debre Berhan, Ethiopia
    Habtemariam Alekaw Habteweld, Debre Berhan University, Debre Berhan, Ethiopia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.