AUTHOR=Bian Chenbin , Zheng Zhuangzhuang , Su Jing , Chang Sitong , Yu Huiyuan , Bao Jindian , Zhao Qin , Jiang Xin 

TITLE=Concurrent chemoradiotherapy with S-1 versus platinum in the treatment of locoregionally advanced nasopharyngeal carcinoma: a multicenter, retrospective, propensity score-matched analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1394754

DOI=10.3389/fphar.2024.1394754

ISSN=1663-9812

ABSTRACT=<sec><title>Objectives</title><p>Literature data are scarce on concurrent chemoradiotherapy (CCRT) with S-1 for locally advanced nasopharyngeal carcinoma (LANPC) treatment. This study compared the efficacy and safety of the S-1 <italic>versus</italic> platinum-based CCRT in LANPC treatment. Methods: This study enrolled 547 patients newly diagnosed with LANPC who underwent CCRT with S-1 or platinum at three institutions. Propensity score matching in a 1:1 ratio balancing baseline features was performed. Survival and adverse effects were compared between groups.</p></sec><sec><title>Results</title><p>Of 160 patients in the cohort, 100 eligible were propensity score matched. Matched dataset analyses showed a higher 5-year overall survival rate (87.1% vs. 84.7%, <italic>P</italic> = 0.833), progression-free survival (79.6% vs. 75.5%, <italic>P</italic> = 0.669), locoregional recurrence-free survival (87.0% vs. 84.7%, <italic>P</italic> = 0.518), and distant metastasis-free survival (84.8% vs. 83.0%, <italic>P</italic> = 0.780) in the S-1 group than in the platinum-based CCRT group, although not statistically significant. Objective response rate (98.0% vs. 88.0%, <italic>P</italic> = 0.117) was significantly higher in the S-1 than in the platinum-based regimen, although it was not statistically reflected. Compared with platinum-based, those undergoing S-1-based chemotherapy demonstrated a higher incidence of grade 3 mucositis (20.0% vs. 2.0%, <italic>P</italic> = 0.016) in the S-1 group and a lower incidence of leukopenia (44.0% vs. 68.0%, <italic>P</italic> = 0.033), neutropenia (28.0% vs. 52.0%, <italic>P</italic> = 0.032), anemia (22.0% vs. 44.0%, <italic>P</italic> = 0.040), nephrotoxicity (4.0% vs. 20.0%, <italic>P</italic> = 0.028), and nausea/vomiting (30.0% vs. 56.0%, <italic>P</italic> = 0.019).</p></sec><sec><title>Conclusion</title><p>The results suggest that S-1 can be used as a concurrent chemotherapy regimen during radiotherapy for patients with LANPC, since it presents a noninferior survival benefit compared with platinum and shows tolerable adverse effects.</p></sec>