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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1393526
This article is part of the Research Topic Gastrointestinal Damage and Metabolic Disorders View all articles

A Scientometrics Analysis and Visualization of Refractory Gastroesophageal Reflux Disease

Provisionally accepted
Nan Zhang Nan Zhang Ming Han Ming Han Qin-Wei Zheng Qin-Wei Zheng Meng-Yuan Zhang Meng-Yuan Zhang Wen-Lan Zhi Wen-Lan Zhi Jing-Jing Li Jing-Jing Li Lin-Xuan Cui Lin-Xuan Cui Jin-Li Tian Jin-Li Tian Yi Wang Yi Wang Fang Shengquan Fang Shengquan *
  • Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

The final, formatted version of the article will be published soon.

    Refractory gastroesophageal reflux disease (refractory GERD) is a heterogeneous disease characterized by unresponsiveness or poor efficacy to proton-pump inhibitors (PPIs). This chronic disorder substantially weakens patients' mental well-being and quality of life, increasing the financial burden on society. Multiple articles have been reported in this area. However, literature involving scientometric analysis of refractory GERD is absent. Therefore, it is necessary to understand the evolution of research themes and the main hotspots of refractory GERD through bibliometric methods.All documents related to refractory GERD based on the WOS Core Collection from January 2000 to November 2023 were selected for analysis. Citespace V 6.1 R6, VOSviewer V 1.6.20, and Scimago Graphica V 1.0.38 were used to perform bibliometric analysis.We collected a total of 241 research articles from 36 countries and 322 institutions, contributed by over 1000 authors. Over the last 20 years, the number of articles in this field has increased year by year, and since 2011, the number of publications has increased dramatically, with 85.89% of the papers. These countries are led by the United States and Japan. GUT had the highest number of citations and DIGESTION had the highest number of publications.Research on standardized diagnosis and management, mechanisms, novel monitoring methods, and innovative drugs and procedures for refractory GERD are the main topics and hotspots in this field. This study also found that neuroimmune interaction is closely related to refractory GERD, which may be a new direction for future mechanism research.Our study is the first bibliometric analysis of the global literature on refractory GERD. This research provides valuable insights for researchers, enabling them to quickly understand the research frontier and hot topics of this field.

    Keywords: Refractory GERD, Scientometrics analysis, visualization, Citespace, Research hotspots

    Received: 29 Feb 2024; Accepted: 18 Jul 2024.

    Copyright: © 2024 Zhang, Han, Zheng, Zhang, Zhi, Li, Cui, Tian, Wang and Shengquan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fang Shengquan, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China

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