AUTHOR=Shen Guangjie , Zhang Weihao , Tu Qiming , Wang Juncheng TITLE=Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway JOURNAL=Frontiers in Pharmacology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1389786 DOI=10.3389/fphar.2024.1389786 ISSN=1663-9812 ABSTRACT=
Osteoarthritis (OA) is a common chronic disease characterized by progressive cartilage degeneration and secondary synovial inflammation. Bergamottin (Ber) is an important natural derivative of the furanocoumarin compound, extracted from natural foods, such as the pulp of grapefruits and pomelos. Ber exhibits several characteristicsthat are beneficial to human health, such as anti-inflammation, antioxidant, and anti-cancer effects. However, the role of Ber in the treatment of OA has not been elucidated to date. Therefore, in the present study,