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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1387866
This article is part of the Research Topic The Molecular Mechanism in Anti-tumor Therapy Resistance View all articles

Prospects of compound of herbal plants as anticancer: A comprehensive review from molecular pathways

Provisionally accepted
Putri Cahaya Situmorang Putri Cahaya Situmorang 1*Syafruddin Ilyas Syafruddin Ilyas 1Rony Abdi Syahputra Rony Abdi Syahputra 1Sony Eka Nugraha Sony Eka Nugraha 1Nik Mohd Afizan Nik Abd Rahman Nik Mohd Afizan Nik Abd Rahman 2
  • 1 Universitas Sumatera Utara, Medan, Indonesia
  • 2 Putra Malaysia University, Selangor Darul Ehsan, Selangor Darul Ehsan, Malaysia

The final, formatted version of the article will be published soon.

    Cancer refers to the proliferation and multiplication of aberrant cells inside the human body, characterized by their capacity to proliferate and infiltrate various anatomical regions. Numerous biochemical pathways and signaling molecules have an impact on the cancer auto biogenesis process. The regulation of crucial cellular processes necessary for cell survival and proliferation, which are triggered by phytochemicals, is significantly influenced by signaling pathways. These pathways or components are regulated by phytochemicals. Medical plants have shown to be a significant reservoir of diverse anticancer medications employed within the realm of chemotherapy. The anticancer effects of phytochemicals are mediated by several methods, including the induction of apoptosis, cessation of the cell cycle, inhibition of kinases, and prevention of carcinogenic substances. This paper provides an analysis of the phytochemistry of seven prominent plant constituents, namely alkaloids, tannins, flavonoids, phenols, steroids, terpenoids, and saponins. The investigation focuses on the involvement of the MAPK/ERK pathway, TNF signaling, death receptors, p53, p38, and actin dynamics. Hence, this review has examined a range of phytochemicals, encompassing their structural characteristics, and potential anticancer mechanisms. It has underscored the significance of bioactive compounds produced from plants in the prevention of cancer, utilizing diverse molecular pathways. In addition, this endeavor also seeks to incentivize scientists to carry out clinical trials on anticancer medications derived from plants.Cancer encompasses a wide range of illnesses characterized by the abnormal growth and multiplication of abnormal cells within the human body. These abnormal cells exhibit the ability to proliferate and invade any region of the organism (Brown et al., 2023). Cancer is considered the second leading cause

    Keywords: Apoptosis, Cancer, Herbal, Molecular pathway, phytochemicals, Plants

    Received: 18 Feb 2024; Accepted: 17 Jun 2024.

    Copyright: © 2024 Situmorang, Ilyas, Syahputra, Nugraha and Nik Abd Rahman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Putri Cahaya Situmorang, Universitas Sumatera Utara, Medan, Indonesia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.