AUTHOR=Isik Bahar , Suleyman Bahadir , Mammadov Renad , Bulut Seval , Yavuzer Bulent , Altuner Durdu , Coban Taha Abdulkadir , Suleyman Halis 

TITLE=Protective effect of cinnamon extract against cobalt-induced multiple organ damage in rats

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1384181

DOI=10.3389/fphar.2024.1384181

ISSN=1663-9812

ABSTRACT=<sec><title>Background</title><p>The role of oxidative stress and inflammation in cobalt (Co) toxicity has been the focus of previous studies. Cinnamon and its main components have been reported to have protective effects in various tissues with antioxidant and anti-inflammatory effects.</p></sec><sec><title>Aims</title><p>In this study, the protective effect of cinnamon extract (CE) against possible Co-induced heart, kidney, and liver damage in rats was investigated biochemically.</p></sec><sec><title>Methods</title><p>Eighteen <italic>albino Wistar</italic>-type male rats were categorized into three groups (<italic>n</italic> = 6 per group): control (CG), CoCL<sub>2</sub>-administered (CoCL<sub>2</sub>), and CE + CoCL<sub>2</sub>-administered (CE + Co) groups. The CE + CoCL<sub>2</sub> group was administered CE (100 mg/kg), and the CoCL<sub>2</sub> and CG groups were administered distilled water orally by gavage. One hour after the administration, Co (150 mg/kg) was administered orally to the CE + CoCL<sub>2</sub> and CoCL<sub>2</sub> groups. This procedure was repeated once daily for 7 days. Then, biochemical markers were studied in the excised heart, kidney, and liver tissues.</p></sec><sec><title>Results</title><p>CoCL<sub>2</sub> increased oxidants and proinflammatory cytokines and decreased antioxidants in heart, kidney, and liver tissues. Heart, kidney, and liver tissue were affected by Co damage. CE treatment suppressed the CoCL<sub>2</sub>-induced increase in oxidants and proinflammatory cytokines and decrease in antioxidants in heart, kidney, and liver tissues. CE treatment has been shown to attenuate cardiac damage by reducing serum troponin I (TpI) and creatine kinase-MB (CK-MB), renal damage by reducing creatinine and blood urea nitrogen (BUN), and liver damage by reducing alanine aminotransferase (ALT) and aspartate aminotransferase (AST).</p></sec><sec><title>Conclusion</title><p>Co induced the production of oxidants and proinflammatory parameters and antioxidant depletion in heart, kidney, and liver tissues of rats. Our experimental results show that CE protects heart, kidney, and liver tissues against oxidative and inflammatory changes induced by CoCLl<sub>2</sub>.</p></sec>