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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1379908
This article is part of the Research Topic Nutraceuticals in Cardiovascular Diseases and their Associated Risk Conditions View all 8 articles

Suppression of NLRP3 inflammasome orchestrates the protective efficacy of tiron against isoprenaline-induced myocardial injury

Provisionally accepted
Doaa Abdelrahaman Doaa Abdelrahaman 1Ola Habotta Ola Habotta 2Ehab S. Taher Ehab S. Taher 3Eman S. Elashry Eman S. Elashry 2Iman A. Ibrahim Iman A. Ibrahim 2Ahmed Abdeen Ahmed Abdeen 4*Ateya Megahed Ateya Megahed 5Reham M. Ibrahim Reham M. Ibrahim 4Hala Anwer Hala Anwer 4Ostan Mihaela Ostan Mihaela 6Rada Olga Rada Olga 6Khairiah M. Alwutayd Khairiah M. Alwutayd 7Dalia H. El-Kashef Dalia H. El-Kashef 2
  • 1 Al-Azhar University, Cairo, Cairo, Egypt
  • 2 Mansoura University, Mansoura, Dakahlia, Egypt
  • 3 Al-Azhar University Hospital, Assiut, Egypt
  • 4 Benha University, Benha, Egypt
  • 5 Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
  • 6 Banat University of Agricultural Sciences and Veterinary Medicine, Timișoara, Romania
  • 7 Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    The major contribution of myocardial damage to global mortalities arouses debate regarding the exploration of new therapeutic strategies for its treatment. Therefore, our study investigated the counteracting effect of tiron against isoprenaline (ISO)-mediated cardiac infarction in mice. Tiron was administered to mice for seven days prior to two consecutive injections of ISO on days eight and nine of the treatment protocol. Tiron significantly reduced the levels of CK-MB, LDH, and AST in serum samples of ISO-challenged mice. A considerable increase in the cardiac antioxidant response was observed in tiron-treated mice as indicated by depletion of MDA and enhancement of antioxidant activities. Furthermore, tiron induced a marked decrease in NLRP3, ASC, and caspase-1 levels accompanied by weak immune reactions of IL-1β, NF-κB, TLR4, and iNOS in the infarct cardiac tissues. Histopathological screening validated these variations observed in the cardiac specimens.Thus, tiron clearly mitigated the oxidative and inflammatory stress by repressing the NLRP3 inflammasome and the TLR4/NF-κB/iNOS signaling cascade.

    Keywords: inflammatory cytokines, Isoproterenol, Myocardial Infarction, NLRP3 inflammasome, Oxidative Stress, Tiron

    Received: 31 Jan 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Abdelrahaman, Habotta, Taher, Elashry, Ibrahim, Abdeen, Megahed, Ibrahim, Anwer, Mihaela, Olga, Alwutayd and El-Kashef. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ahmed Abdeen, Benha University, Benha, Egypt

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