AUTHOR=Zou Xinyi , Zhang Zixuan , Lu Hui , Zhao Wei , Pan Lanying , Chen Yuan 

TITLE=Functional effects of drugs and toxins interacting with NaV1.4

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1378315

DOI=10.3389/fphar.2024.1378315

ISSN=1663-9812

ABSTRACT=<p>Na<sub>V</sub>1.4 is a voltage-gated sodium channel subtype that is predominantly expressed in skeletal muscle cells. It is essential for producing action potentials and stimulating muscle contraction, and mutations in Na<sub>V</sub>1.4 can cause various muscle disorders. The discovery of the cryo-EM structure of Na<sub>V</sub>1.4 in complex with β1 has opened new possibilities for designing drugs and toxins that target Na<sub>V</sub>1.4. In this review, we summarize the current understanding of channelopathies, the binding sites and functions of chemicals including medicine and toxins that interact with Na<sub>V</sub>1.4. These substances could be considered novel candidate compounds or tools to develop more potent and selective drugs targeting Na<sub>V</sub>1.4. Therefore, studying Na<sub>V</sub>1.4 pharmacology is both theoretically and practically meaningful.</p>