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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1376850

Retrospective analysis of the effect of SGLT-2 inhibitors on renal function in patients with type 2 diabetes in the real world

Provisionally accepted
Rongjing Song Rongjing Song 1Qiaoyu Hou Qiaoyu Hou 2Xiuying Zhang Xiuying Zhang 3,4Gang Liu Gang Liu 1Meng Li Meng Li 3Xiaohong Zhang Xiaohong Zhang 5*Linong Ji Linong Ji 3,4*
  • 1 Department of Pharmacy, Peking University People's Hospital, Beijing, Beijing Municipality, China
  • 2 Department of Clinical Pharmacy, Qilu Hospital Shandong University, Dezhou, China
  • 3 Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, Beijing Municipality, China
  • 4 Peking University Diabetes Centre, Beijing, China
  • 5 Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    The protective effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on the kidneys has been widely recognized. However, limited research has reported the changes in estimated glomerular filtration rate (eGFR) of real-world patients with type 2 diabetes mellitus (T2DM) over time after administration of SGLT-2 inhibitors. This study aimed to reflect the trend of eGFR changes over time in T2DM patients having different baseline eGFR after SGLT-2 inhibitors administration in the real world.Methods: A single-center retrospective study was performed in a tertiary public hospital in Beijing, China. In total, 998 outpatients with T2DM who initiated SGLT-2 inhibitors treatment were included in the study. The changes in eGFR, urinary albumin/creatinine ratio (UACR), and glycolipid metabolism indicators were analyzed during the 18-month follow-up period.The eGFR levels significantly decreased to their lowest point (-3.04 mL/min/1.73 m 2 ) in the first three months after initiation of SGLT-2 inhibitors treatment, however, gradually returned to the baseline level after one year.Compared to the subgroup with eGFR > 90 mL/min/1.73 m 2 , improvements in renal function were more significant in patients with T2DM from the 60 < eGFR ≤ 90 mL/min/1.73 m 2 and eGFR ≤ 60 mL/min/1.73 m 2 subgroups after treatment with SGLT-2 inhibitors. Similarly, SGLT-2 inhibitors reduced the UACR in patients with diabetic nephropathy.This study further confirmed the real-world long-term protective effect of SGLT-2 inhibitors on the kidneys of patients with T2DM, which is not related to baseline renal function and blood glucose.

    Keywords: Sodium-glucose cotransporter-2 inhibitors, type 2 diabetes mellitus, Renal function, Estimated glomerular filtration rate, Urinary albumin/creatinine ratio

    Received: 26 Jan 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Song, Hou, Zhang, Liu, Li, Zhang and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaohong Zhang, Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
    Linong Ji, Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, 100044, Beijing Municipality, China

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