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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1367812
This article is part of the Research Topic Emerging Trends in the Quality Check of Herbal Medicines, Supplements and 'Botanicals' View all articles

Efficacy of Hongjing I Granule, an Herbal Medicine, in Patients with Mild to Moderate Erectile Dysfunction in a Randomized Controlled Trial

Provisionally accepted
Runnan Xu Runnan Xu 1Jun Guo Jun Guo 2Chun-He Zhang Chun-He Zhang 3Qing Zhou Qing Zhou 4Qiang Gen Qiang Gen 5,6Fu Wang Fu Wang 2Yu Zhao Yu Zhao 6,7Xin-Yun Luo Xin-Yun Luo 4Yan-Feng Li Yan-Feng Li 3Yi-Jia Fu Yi-Jia Fu 1Xin Zhang Xin Zhang 1Wen-Zhi Wang Wen-Zhi Wang 8Jian-Xiong Ma Jian-Xiong Ma 1Jian Wang Jian Wang 9Xiao-Jun Huang Xiao-Jun Huang 10Wen-Jie Huang Wen-Jie Huang 10Bodong Lv Bodong Lv 10*
  • 1 Zhejiang Chinese Medical University, Hangzhou, China
  • 2 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
  • 3 Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan Province, China
  • 4 The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
  • 5 Andrology Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin, China
  • 6 National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, tianjing, China
  • 7 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin, China
  • 8 Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
  • 9 Quzhou Hospital of Traditional Chinese Medicine, Quzhou, China
  • 10 Department of Urology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    In both primary outcomes, HJIG proved superior to the placebo. Additionally, improvements in TCM symptom scores were notably greater in the HJIG group relative to the placebo, with no adverse events reported across both groups.The Hongjing I granule significantly markedly improved outcomes symptoms forin patients with mild to moderate ED. However, to validate these findings, further extended randomized trials are warranted.The study has been registered in the Chinese Clinical Trial Registry (ChiCTR) and the registration number was ChiCTR2000041127.

    Keywords: Chinese herbal formula, randomized control trial, Hongjing I granule, Erectile Dysfunction, complementary and alternative medicine

    Received: 09 Jan 2024; Accepted: 17 Sep 2024.

    Copyright: © 2024 Xu, Guo, Zhang, Zhou, Gen, Wang, Zhao, Luo, Li, Fu, Zhang, Wang, Ma, Wang, Huang, Huang and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bodong Lv, Department of Urology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.