AUTHOR=Chang Kaixin , Guo Rui , Hu Wenbo , Wang Xuezhu , Cao Feiwei , Qiu Jiannan , Li Jiaomei , Han Qiang , Du Zhongyan , Dou Xiaobing , Li Songtao 

TITLE=Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1363131

DOI=10.3389/fphar.2024.1363131

ISSN=1663-9812

ABSTRACT=<p>This study aimed to evaluate the protective role and potential mechanisms of Xie Zhuo Tiao Zhi decoction (XZTZ) on alcohol-associated liver disease (ALD). XZTZ significantly alleviated alcohol-induced liver dysfunction, based on histological examinations and biochemical parameters after 4-week administration. Mechanically, alcohol-stimulated hepatic oxidative stress was ameliorated by XZTZ, accompanied by the improvement of Nrf2/Keap1 expression and alcohol-activated phosphorylation of pro-inflammatory transcription factors, including JNK, P38, P65, and IκBα, were rescued by XZTZ. In conclusion, XZTZ demonstrates potential in alleviating alcohol-induced liver injury, oxidative stress, and inflammation possibly through modulation of Nrf2/Keap1 and MAPKs/NF-κB signaling pathways, suggesting its potential as a therapeutic option for patients with alcoholic liver disease.</p>