AUTHOR=Girão Mariana , Freitas Sara , Martins Teresa P. , Urbatzka Ralph , Carvalho Maria F. , Leão Pedro N. 

TITLE=Decylprodigiosin: a new member of the prodigiosin family isolated from a seaweed-associated Streptomyces

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1347485

DOI=10.3389/fphar.2024.1347485

ISSN=1663-9812

ABSTRACT=<p>Bioprospecting actinobacterial secondary metabolism from untapped marine sources may lead to the discovery of biotechnologically-relevant compounds. While studying the diversity and bioactive potential of Actinomycetota associated with <italic>Codium tomentosum,</italic> a green seaweed collected in the northern Portuguese cost, strain CT-F61, identified as <italic>Streptomyces violaceoruber</italic>, was isolated. Its extracts displayed a strong anticancer activity on breast carcinoma T-47D and colorectal carcinoma HCT116 cells, being effective as well against a panel of human and fish pathogenic bacteria. Following a bioactivity-guided isolation pipeline, a new analogue of the red-pigmented family of the antibiotics prodigiosins, decylprodigiosin (1), was identified and chemically characterized. Despite this family of natural products being well-known for a long time, we report a new analogue and the first evidence for prodigiosins being produced by a seaweed-associated actinomycete.</p>