AUTHOR=Gao Jianjun , Shi Wujiang , Wang Jiangang , Guan Canghai , Dong Qingfu , Sheng Jialin , Zou Xinlei , Xu Zhaoqiang , Ge Yifei , Yang Chengru , Li Jiehan , Bao Haolin , Zhong Xiangyu , Cui Yunfu TITLE=Research progress and applications of epigenetic biomarkers in cancer JOURNAL=Frontiers in Pharmacology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1308309 DOI=10.3389/fphar.2024.1308309 ISSN=1663-9812 ABSTRACT=

Epigenetic changes are heritable changes in gene expression without changes in the nucleotide sequence of genes. Epigenetic changes play an important role in the development of cancer and in the process of malignancy metastasis. Previous studies have shown that abnormal epigenetic changes can be used as biomarkers for disease status and disease prediction. The reversibility and controllability of epigenetic modification changes also provide new strategies for early disease prevention and treatment. In addition, corresponding drug development has also reached the clinical stage. In this paper, we will discuss the recent progress and application status of tumor epigenetic biomarkers from three perspectives: DNA methylation, non-coding RNA, and histone modification, in order to provide new opportunities for additional tumor research and applications.