AUTHOR=Zhou Chenyu , Xia Quan , Hamezah Hamizah Shahirah , Fan Zheng , Tong Xiaohui , Han Rongchun 

TITLE=Efficacy of Forsythia suspensa (Thunb.) Vahl on mouse and rat models of inflammation-related diseases: a meta-analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1288584

DOI=10.3389/fphar.2024.1288584

ISSN=1663-9812

ABSTRACT=<p><bold>Objective:</bold> To evaluate the efficacy of the fruits of the medicinal plant <italic>Forsythia suspensa</italic> (Thunb.) Vahl (FS), in treating inflammation-associated diseases through a meta-analysis of animal models, and also probe deeply into the signaling pathways underlying the progression of inflammation.</p><p><bold>Materials and methods:</bold> All data analyses were performed using Review Manager 5.3 and the results are presented as flow diagrams, risk-of-bias summaries, forest plots, and funnel plots. Summary estimates were calculated using a random- or fixed-effect model, depending on the value of I2.</p><p><bold>Results:</bold> Of the 710 records identified in the initial search, 11 were selected for the final meta-analysis. Each study extracted data from the model and treatment groups for analysis, and the results showed that FS alleviated the inflammatory cytokine levels in serum; oxidant indicator: reactive oxygen species; enzymes of liver function; endotoxin and regulatory cells in blood; and improved the antioxidant enzyme superoxide dismutase.</p><p><bold>Conclusion:</bold> FS effectively reversed the change in acute or chronic inflammation indicators in animal models, and the regulation of multiple channel proteins in inflammatory signaling pathways suggests that FS is a good potential drug for inflammatory disease drug therapy.</p>