AUTHOR=Hooshiar Mohammad Hosseini , Sholeh Mohammad , Beig Masoumeh , Azizian Khalil , Kouhsari Ebrahim TITLE=Global trends of antimicrobial resistance rates in Neisseria gonorrhoeae: a systematic review and meta-analysis JOURNAL=Frontiers in Pharmacology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1284665 DOI=10.3389/fphar.2024.1284665 ISSN=1663-9812 ABSTRACT=Background

Antimicrobial resistance (AMR) of Neisseria gonorrhoeae (NG) is a significant public health concern.

Objective

The objective of our study was to assess global AMR rates and test them both temporally and geographically.

Methods

We conducted a systematic search of relevant reports from international databases up to 2021. The R statistical package was used for all statistical analyses.

Results

A total of 225 articles were analyzed, and 432,880 NG isolates were examined. The weighted pooled resistance (WPR) rate of different antibiotics was as follows: ciprofloxacin, 51.6%; tetracycline, 45.4%; trimethoprim/sulfamethoxazole, 42.4%; chloramphenicol, 4.1%; kanamycin, 2.1%; gentamicin, 0.6%; and spectinomycin, 0.3%. The resistance to spectinomycin, gentamicin, and kanamycin decreased over time. Significant differences in antibiotic resistance rates were found between the countries.

Conclusion

Our findings reveal a continuous increase in resistance to some antibiotics (tetracycline and ciprofloxacin) historically used for gonorrhea, even after discontinuation. However, encouraging trends of decreasing resistance to spectinomycin, gentamicin, and kanamycin were observed. Continued global monitoring of AMR profiles in NG isolates is essential for informing appropriate treatment strategies and mitigating the threat of untreatable gonorrhea.