AUTHOR=Yang Shiyu , Chen Heming , Su Wei , Luo Yunchun , Liao Jun , Wang Yun , Xiong Liyan , Zhang Chuan , Li Fei , Chen Zhe-Sheng , Wang Tingfang 

TITLE=Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1297124

DOI=10.3389/fphar.2023.1297124

ISSN=1663-9812

ABSTRACT=<p>Ischemia-reperfusion (I/R) injury refers to a new injury caused by reperfusion after the restoration of ischemic tissue or organ blood supply. Salvianic acid A (danshensu) is a primary active ingredient extracted from <italic>Salvia miltiorrhiza</italic>. It has a protective function against I/R injury in the cardiovascular system, brain, liver, kidney, gastrointestinal tract, and other organs. This article reviews evidence of the protective effects of Salvianic acid A and its potential mechanisms of action in organ I/R injury protection. The aim of this review is to investigate the role of Salvianic acid A in the treatment of I/R injury, providing a reference resource that could facilitate subsequent studies.</p>