AUTHOR=Balsera-Manzanero María , Ghirga Francesca , Ruiz-Molina Ana , Mori Mattia , Pachón Jerónimo , Botta Bruno , Cordero Elisa , Quaglio Deborah , Sánchez-Céspedes Javier TITLE=Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1293296 DOI=10.3389/fphar.2023.1293296 ISSN=1663-9812 ABSTRACT=
Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity in immunosuppressed patients, a specific treatment is still not yet available. In this study, we screened the CM1407 COST Action’s chemical library, comprising 1,233 natural products to identify compounds that restrict HAdV infection. Among them, we identified rotenolone, a compound that significantly inhibited HAdV infection. Next, we selected four isoflavonoid-type compounds (e.g., rotenone, deguelin, millettone, and tephrosin), namely rotenoids, structurally related to rotenolone in order to evaluate and characterized