AUTHOR=Stewart Stefan , Dodero-Anillo Jose Manuel , Guijarro-Eguinoa Javier , Arias Pedro , Gómez López De Las Huertas Arturo , Seco-Meseguer Enrique , García-García Irene , Ramírez García Elena , Rodríguez-Antolín Carlos , Carcas Antonio J. , Rodriguez-Novoa Sonia , Rosas-Alonso Rocio , Borobia Alberto M. TITLE=Advancing pharmacogenetic testing in a tertiary hospital: a retrospective analysis after 10 years of activity JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1292416 DOI=10.3389/fphar.2023.1292416 ISSN=1663-9812 ABSTRACT=

The field of pharmacogenetics (PGx) holds great promise in advancing personalized medicine by adapting treatments based on individual genetic profiles. Despite its benefits, there are still economic, ethical and institutional barriers that hinder its implementation in our healthcare environment. A retrospective analysis approach of anonymized data sourced from electronic health records was performed, encompassing a diverse patient population and evaluating key parameters such as prescribing patterns and test results, to assess the impact of pharmacogenetic testing. A head-to-head comparison with previously published activity results within the same pharmacogenetic laboratory was also conducted to contrast the progress made after 10 years. The analysis revealed significant utilization of pharmacogenetic testing in daily clinical practice, with 1,145 pharmacogenetic tests performed over a 1-year period and showing a 35% growth rate increase over time. Of the 17 different medical departments that sought PGx tests, the Oncology department accounted for the highest number, representing 58.47% of all genotyped patients. A total of 1,000 PGx tests were requested for individuals susceptible to receive a dose modification based on genotype, and 76 individuals received a genotype-guided dose adjustment. This study presents a comprehensive descriptive analysis of real-world data obtained from a public tertiary hospital laboratory specialized in pharmacogenetic testing, and presents data that strongly endorse the integration of pharmacogenetic testing into everyday clinical practice.