AUTHOR=Zhang Yaoyin , Chen Wei , Chen Junming , Li Mingmei , Huang Yulan , Min Wenjiao 

TITLE=Persistent hiccups due to aripiprazole: a case report and review of the literature

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1284510

DOI=10.3389/fphar.2023.1284510

ISSN=1663-9812

ABSTRACT=<p><bold>Introduction:</bold> Aripiprazole, a commonly prescribed antipsychotic, has been rarely associated with the onset of hiccups. This study aims to elucidate the prevalence, risk factors, and management of aripiprazole-induced hiccups.</p><p><bold>Methods:</bold> We report a case of aripiprazole-induced hiccups in a 32-year-old male diagnosed with Somatic Symptom Disorder per DSM-5 criteria.A comprehensive literature review was conducted, identifying 29 case reports of aripiprazole-induced hiccups. Patient demographics, dosage, onset and duration of hiccups, and management strategies were analyzed.</p><p><bold>Results:</bold> Aripiprazole-induced hiccups predominantly affected adolescents and middle-aged male patients (86.7%). The majority of hiccups developed within 1–2 days post-prescription (90.9%) and resolved within 1–4 days after discontinuation of aripiprazole. Discontinuation of aripiprazole was the most effective management strategy (51.7%). Co-administration with benzodiazepines was identified as a significant risk factor.</p><p><bold>Discussion:</bold> The findings suggest that clinicians should be vigilant for the onset of hiccups during the early stages of aripiprazole treatment, especially in male patients and those co-administered with benzodiazepines.</p><p><bold>Conclusion:</bold> Clinicians should be vigilant for hiccups during early aripiprazole treatment. Considering personality and psychological factors is crucial in managing hiccups in psychiatric patients.</p>