AUTHOR=Li Xiaonan , Lu Lehua , He Ying , Zhang Hui , Zhang Yihui , Sheng Huaquan , Chen Ming , Ru Jiexiong , Gao Yihan 

TITLE=Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1279512

DOI=10.3389/fphar.2023.1279512

ISSN=1663-9812

ABSTRACT=With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts. Nicotine increases the release of dopamine (DA) into the nucleus accumbens (NAc), causing feelings of satisfaction. However, the differences in the DA-increasing effects of different nicotine salts have not been reported. In this study, we used a G protein-coupled receptor-activated DA fluorescent probe (GRABDA1m) and optical fiber photometric recording equipment to monitor the dynamic changes and kinetics of DA release in the NAc of mice exposed to different e-cigarette aerosols, including nicotine, nicotine benzoate, nicotine tartrate, nicotine lactate, nicotine levulinic acid, nicotine malate, and nicotine citrate. The results of this study were as follows: (1) Different types of nicotine salts could increase the release of DA in the NAc.