AUTHOR=Cao Yu-Xia , Ji Peng , Wu Fan-Lin , Dong Jia-Qi , Li Chen-Chen , Ma Ting , Yang Hao-Chi , Wei Yan-Ming , Hua Yong-Li 

TITLE=Lonicerae Japonicae Caulis: a review of its research progress of active metabolites and pharmacological effects

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1277283

DOI=10.3389/fphar.2023.1277283

ISSN=1663-9812

ABSTRACT=<p><italic>Lonicerae Japonicae Caulis</italic> is the aboveground stem part of the <italic>Lonicera Japonica</italic> Thunb, which belongs to the medicine food homology species in China. It has the effects of clearing away heat, toxic material, dredging wind and unblocking collaterals. Modern research shows that it contains various active metabolites and a wide range of pharmacological effects, which is of great research and clinical application value. It mainly contains organic acids, volatile oils, flavonoids, triterpenes, triterpene saponins and other active metabolites. Its pharmacological effects mainly include anti-inflammatory, antibacterial, antitumor, antioxidant, and repairing bone and soft tissue. Based on the literature reports in recent years, the active metabolites, pharmacological effects and mechanisms of <italic>Lonicerae Japonicae Caulis</italic> were sorted out and summarized. It lays a foundation for explaining the efficacy material basis and application value of <italic>Lonicerae Japonicae Caulis</italic>. It aims to provide a reference for the in-depth research, development and utilization of <italic>Lonicerae Japonicae Caulis</italic>.</p>