AUTHOR=Liu Yang , Qiu Weiyan , Li Longyu , Chen Rongchang , Kang Yan , Ruan Shuangchen TITLE=A novel approach to pulmonary bronchial tree model construction and performance index study JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1254804 DOI=10.3389/fphar.2023.1254804 ISSN=1663-9812 ABSTRACT=

The demand for respiratory disease and dynamic breathing studies has continuously driven researchers to update the pulmonary bronchial tree’s morphology model. This study aims to construct a bronchial tree morphology model efficiently and effectively with practical algorithms. We built a performance index system using failure branch rate, volume ratio, and coefficient of variation of terminal volumes to evaluate the model performance. We optimized the parameter settings and found the best options to build the morphology model, and we constructed a 14th-generation bronchial tree model with a decent performance index. The dimensions of our model closely matched published data from anatomic in vitro measurements. The proposed model is adjustable and computable and will be used in future dynamic breathing simulations and respiratory disease studies.