AUTHOR=Salvador Elena , Mazzi Cristina , De Santis Nicoletta , Bertoli Giulia , Jonjić Antonija , Coklo Miran , Majdan Marek , Peñalvo José L. , Buonfrate Dora 

TITLE=Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1252800

DOI=10.3389/fphar.2023.1252800

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> Effective domiciliary treatment can be useful in the early phase of COVID-19 to limit disease progression, and pressure on hospitals. There are discrepant data on the use of non-steroidal anti-inflammatory drugs (NSAIDs). Aim of this study is to evaluate whether the clinical outcome of patients who were hospitalized for COVID-19 is influenced by domiciliary treatment with NSAIDs. Secondary objective was to explore the association between other patient characteristics/therapies and outcome.</p><p><bold>Methods:</bold> A large dataset of COVID-19 patients was created in the context of a European Union-funded project (unCoVer). The primary outcome was explored using a study level random effects meta-analysis for binary (multivariate logistic regression models) outcomes adjusted for selected factors, including demographics and other comorbidities.</p><p><bold>Results:</bold> 218 out of 1,144 patients reported use of NSAIDs before admission. No association between NSAIDs use and clinical outcome was found (unadj. OR: 0.96, 95%CI: 0.68-1.38). The model showed an independent upward risk of death with increasing age (OR 1.06; 95% CI 1.05-1.07) and male sex (1.36; 95% CI 1.04-1.76).</p><p><bold>Conclusion:</bold> In our study, the domiciliary use of NSAIDs did not show association with clinical outcome in patients hospitalized with COVID-19. Older ages and male sex were associated to an increased risk of death.</p>