This article is a correction to:
Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients
Nenad Neskovic1,2*
Dario Mandic2,3
Saska Marczi2,4
Sonja Skiljic1,2Gordana Kristek1,2
Hrvoje Vinkovic1,2
Boris Mraovic5
Zeljko Debeljak2,3
Slavica Kvolik1,2*- 1Department of Anesthesiology, Resuscitation and ICU, Osijek University Hospital, Osijek, Croatia
- 2Faculty of Medicine, University Josip Juraj Strossmayer, Osijek, Croatia
- 3Department of Clinical and Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia
- 4Laboratory for Molecular and HLA Diagnostic, Department of Transfusion Medicine, Osijek University Hospital, Osijek, Croatia
- 5University of Missouri, Department of Anesthesiology and Perioperative Medicine, School of Medicine, Columbia, MO, United States
by Neskovic N, Mandic D, Marczi S, Skiljic S, Kristek G, Vinkovic H, Mraovic B, Debeljak Z and Kvolik S (2021). Front. Pharmacol. 12:656748. doi: 10.3389/fphar.2021.656748
In the published article, there was an error in Figure 1 as published. The Figures 1B, C were incorrect and appeared inverted in the figure caption.
FIGURE 1
FIGURE 1. Concentrations of tramadol (A), N-demethyltramadol (B), and O-demethyltramadol (C) in the first 24 postoperative hours. Concentrations were measured 1, 2, 4 h after the first dose of 100 mg tramadol iv, and just before the second (time point 6 h), third (time point 12 h), and fifth (time point 24 h) doses of tramadol. PM, poor metabolizer; IM, intermediate metabolizer; EM, extensive metabolizer; UM, ultrafast metabolizers; Dot, tramadol 100 mg IV injections; * statistically significant differences (Mann-Whitney U test) between PM and EM/IM (B), and EM and IM/PM (C).
The corrected Figure 1 and its caption appear below.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: postoperative analgesia, postoperative pain, inflammation, cholinesterase, CYP2D6, O-demethyltramadol, N-demethyltramadol, tramadol
Citation: Neskovic N, Mandic D, Marczi S, Skiljic S, Kristek G, Vinkovic H, Mraovic B, Debeljak Z and Kvolik S (2023) Corrigendum: Different pharmacokinetics of tramadol, O-demethyltramadol and N-demethyltramadol in postoperative surgical patients from those observed in medical patients. Front. Pharmacol. 14:1250698. doi: 10.3389/fphar.2023.1250698
Received: 30 June 2023; Accepted: 31 July 2023;
Published: 22 August 2023.
Edited and reviewed by:
Carl-Olav Stiller, Karolinska Institutet (KI), SwedenCopyright © 2023 Neskovic, Mandic, Marczi, Skiljic, Kristek, Vinkovic, Mraovic, Debeljak and Kvolik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Slavica Kvolik, skvolik@mefos.hr; Nenad Neskovic, nneskov@gmail.com