AUTHOR=Silva Jéssica Manoelli Costa , Teixeira Eliel Barbosa , Mourão Ronald Matheus da Silva , Ferraz Rafaella Sousa , Moreira Fabiano Cordeiro , Assumpção Paulo Pimentel de , Calcagno Danielle Queiroz 

TITLE=The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1237723

DOI=10.3389/fphar.2023.1237723

ISSN=1663-9812

ABSTRACT=<p>Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.</p>