AUTHOR=Ibrahim Traore S. , Khongorzul Purevdulam , Muyaba Moses , Alolga Raphael N. 

TITLE=Ent-kaurane diterpenoids from the Annonaceae family: a review of research progress and call for further research

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1227574

DOI=10.3389/fphar.2023.1227574

ISSN=1663-9812

ABSTRACT=<p>The Annonaceae is one of the plant families with members that are credited with numerous pharmacological functions. Among the group of compounds responsible for these bioactivities are the <italic>ent</italic>-kaurane diterpenoids. The <italic>ent</italic>-kauranes are a group of 20-Carbon, tetracyclic diterpenoids that are widely distributed in other plant families including the Annonaceae family. This mini-review focuses mainly on the <italic>ent</italic>-kaurane diterpenoids isolated from the Annonaceae family, delineates the various biological activities of these compounds, and highlights the research gaps that exist for further scientific scrutiny.</p>