AUTHOR=Si Shangkun , Zhao Xiaohu , Su Fan , Lu Hongxiu , Zhang Dongbin , Sun Li , Wang Fulei , Xu Li 

TITLE=New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1227496

DOI=10.3389/fphar.2023.1227496

ISSN=1663-9812

ABSTRACT=<p>Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic anti-inflammatory pathway, affecting perioperative neurocognitive function. This article reviews the relevant research evidence over the past 20 years, intending to provide new perspectives and strategies for the clinical application of neostigmine.</p>