AUTHOR=Yuandani  , Jantan Ibrahim , Haque Md. Areeful , Rohani Ade Sri , Nugraha Sony Eka , Salim Emil , Septama Abdi Wira , Juwita Nur Aira , Khairunnisa Nur Aini , Nasution Halimah Raina , Utami Dinda Sari , Ibrahim Sarah 

TITLE=Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1222195

DOI=10.3389/fphar.2023.1222195

ISSN=1663-9812

ABSTRACT=<p><italic>Zingiber</italic> and <italic>Alpinia</italic> species (family: Zingiberaceae) are popularly used in food as spices and flavoring agents and in ethnomedicine to heal numerous diseases, including immune-related disorders. However, their ethnomedicinal uses have not been sufficiently supported by scientific investigations. Numerous studies on the modulating effects of plants and their bioactive compounds on the different steps of the immune system have been documented. This review aimed to highlight up-to-date research findings and critically analyze the modulatory effects and mechanisms of the extracts and secondary compounds of several <italic>Zingiber</italic> and <italic>Alpinia</italic> species, namely, <italic>Zingiber officinale</italic> Roscoe, <italic>Z. cassumunar</italic> Roxb., <italic>Z. zerumbet</italic> (L.) Roscoe ex Sm., <italic>Alpinia galanga</italic> Linn., <italic>A. conchigera</italic> Griff, <italic>A. katsumadai</italic> Hayata, <italic>A. oxyphylla</italic> Miq., <italic>A. officinarum</italic> Hance, <italic>A. zerumbet</italic> (Pers.) Burtt. et Smith, and <italic>A. purpurata</italic> (Viell.) K. Schum. on the immune system, particularly via the inflammation-related signaling pathways. The immunomodulating activities of the crude extracts of the plants have been reported, but the constituents contributing to the activities have mostly not been identified. Among the extracts, <italic>Z. officinale</italic> extracts were the most investigated for their <italic>in vitro</italic>, <italic>in vivo</italic>, and clinical effects on the immune system. Among the bioactive metabolites, 6-, 8-, and 10-gingerols, 6-shogaol, and zerumbone from <italic>Zingiber</italic> species and cardamomin, 1′-acetoxychavicol acetate, yakuchinone, rutin, 1,8-cineole, and lectin from <italic>Alpinia</italic> species have demonstrated strong immunomodulating effects. More experimental studies using cell and animal models of immune-related disorders are necessary to further understand the underlying mechanisms, together with elaborate preclinical pharmacokinetics, pharmacodynamics, bioavailability, and toxicity studies. Many of these extracts and secondary metabolites are potential candidates for clinical development in immunomodulating agents or functional foods to prevent and treat chronic inflammatory disorders.</p>