AUTHOR=Park Hyeri , Lin Mingliang , Zhou Jian , Eubanks Lisa M. , Zhou Bin , Janda Kim D. TITLE=Development of a vaccine against the synthetic opioid U-47700 JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1219985 DOI=10.3389/fphar.2023.1219985 ISSN=1663-9812 ABSTRACT=
Opioid use disorders and overdose have become a major public health concern in recent years. U-47700, a New psychoactive substances (NPS) opioid, also known as “pinky” or “pink” has been identified as a new threat in the drug supply because of its potency and abuse potential. Conjugate vaccines that can produce antibodies against target drug molecules have emerged as a promising tool to treat substance use disorders. Herein, we report the design, synthesis, and