AUTHOR=Wang Li Ying , Wang Jin , Dong Jin Hua , Ping Ze Peng , Chen Xin Zhong , Wei Chang Na TITLE=The optimal oxytocin infusion rate for preventing uterine atony during cesarean delivery in elderly parturients with prior history of cesarean delivery JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1211693 DOI=10.3389/fphar.2023.1211693 ISSN=1663-9812 ABSTRACT=

Background: An estimate of 90% effective dose (ED90) of oxytocin infusion has already been proved effective in non-laboring parturients. However, the requirements of oxytocin for elderly parturients with prior history of cesarean delivery (CD) may be higher. The aim of this study was to find the optimum oxytocin infusion rate for preventing uterine atony during CD in elderly parturients with prior history of CD.

Method: We performed a randomized, double-blinded study in 120 healthy elderly parturients with prior history of CD scheduled for elective CD under combined spinal–epidural (CSE) anesthesia. Participants were treated with oxytocin infusion randomly at the rates of 0, 4, 8, 12, 16, or 20 IU h⁻¹ after the delivery of infants. Following oxytocin administration, a blinded obstetrician evaluated the uterine tone (UT), verbally describing it using numerical scales (0–10: 0, no UT; 10, optimal UT) as either adequate or inadequate at the time intervals of 3, 6, and 9 min. Maternal adverse effects, requirements for additional uterotonic agents, delivery–placenta delivery time (PD), and estimated blood loss (EBL) were recorded.

Results: The 50% effective dose (ED50) and 90% effective dose (ED90) of oxytocin infusion were 14.6 IU h⁻¹ (95% confidence interval 12.0–18.4 IU h⁻¹) and 27.7 IU h⁻¹ (95% confidence interval 22.5–39.4 IU h⁻¹), respectively. As the rate of infusion was increased in parturients, the rescue oxytocin dose and delivery-PD time were decreased. Parturients who received 0 IU h⁻¹ oxytocin at 3, 6, and 9 min obtained lower UT scores than those who received 16 and 20 IU h⁻¹ oxytocin (p < 0.05, respectively). No significant differences were observed among groups in EBL and maternal adverse effects.

Conclusion: The infusion rate of oxytocin at 14.57 and 27.74 IU h⁻¹ produces adequate UT in 50% and 90% of elderly parturients with prior history of CD, respectively. An oxytocin infusion rate of 27.7 IU h⁻¹ is suggested to be the optimal dose for preventing uterine atony during CD in elderly parturients with prior history of cesarean delivery.

Clinical Trial Registration: [https://www.chictr.org.cn/bin/project/edit?pid=62489], Identifier: [ChiCTR2000038891].