AUTHOR=Armentaro Giuseppe , D’Arrigo Graziella , Bo Mario , Cassano Velia , Miceli Sofia , Pitino Annalisa , Tripepi Giovanni , Romeo Santina Maria Grazia , Sesti Giorgio , Lip Gregory Y. H. , Pastori Daniele , Gori Mercedes , Sciacqua Angela 

TITLE=Medium-term and long-term renal function changes with direct oral anticoagulants in elderly patients with atrial fibrillation

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1210560

DOI=10.3389/fphar.2023.1210560

ISSN=1663-9812

ABSTRACT=<p><bold>Objective:</bold> Atrial Fibrillation (AF) and chronic kidney disease frequently coexist in the elderly. Warfarin-like drugs (WLDs) may be associated with a relatively greater decrease of estimated glomerular filtration rate (eGFR) as compared to direct oral anticoagulants (DOACs), but there is no evidence on the medium- and long-term changes. To further elucidate this issue in elderly patients with AF, we investigated the renal function deterioration in the two groups of the study (DOACs or WLDs).</p><p><bold>Patients and Methods:</bold> A total of 420 AF patients were enrolled (mean age: 77.0 ± 6.0 years; 136 on WLDs and 284 on DOACs). These patients underwent three eGFR measurements during the follow-up period. The between-arms difference of eGFR decline over time was investigated by Linear Mixed Models and group-based trajectory model analyses.</p><p><bold>Results:</bold> In the whole study cohort, after a median follow-up of 4.9 years (interquartile range: 2.7–7.0 years), eGFR decreased from 67.4 ± 18.2 to 47.1 ± 14.3 mL/min/1.73 m<sup>2</sup> (<italic>p</italic> &lt; 0.001). Remarkably, patients on DOACs experienced a significantly smaller eGFR decline than WLDs patients (−21.3% vs. −45.1%, <italic>p</italic> &lt; 0.001) and this was true both in the medium-term (−6.6 vs. −19.9 mL/min/1.73 m<sup>2</sup>) and in the long-term (−13.5 <italic>versus</italic> −34.2 mL/min/1.73 m<sup>2</sup>) period. After stratification into five subgroups according to trajectories of renal function decline over time, logistic regression showed that DOACs patients had from 3.03 to 4.24-fold greater likelihood to belong to the trajectory with less marked eGFR decline over time than WLDs patients.</p><p><bold>Conclusion:</bold> Elderly patients with AF on treatment with DOACs had a relatively smaller decline of eGFR over time compared to those on treatment with WLDs. This is consistent with what was partly reported in the literature.</p>