AUTHOR=Ejaz Afaf , Waliat Sadaf , Arshad Muhammad Sajid , Khalid Waseem , Khalid Muhammad Zubair , Rasul Suleria Hafiz Ansar , Luca Marian-Ilie , Mironeasa Costel , Batariuc Ana , Ungureanu-Iuga Mădălina , Coţovanu Ionica , Mironeasa Silvia TITLE=A comprehensive review of summer savory (Satureja hortensis L.): promising ingredient for production of functional foods JOURNAL=Frontiers in Pharmacology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1198970 DOI=10.3389/fphar.2023.1198970 ISSN=1663-9812 ABSTRACT=This review aims to measure the different aspects of summer savory including biological activity, medicinal properties, nutritional value, food application, health prospective and their usage as a feed additive in broilers. However, the herb-related toxicity is also overviewed. Summer savory leaves are abundant in total phenolic compounds (rosmarinic acid and flavonoids) that have an powerful antioxidant impact. The rosmarinic (𝛼-O-caffeoyl-3,4-dihydroxy-phenyl lactic) acid are identified in summer savory as a main component. According to phytochemical investigations, tannins, volatile oils, sterols, acids, gums, pyrocatechol, phenolic compounds, mucilage and pyrocatechol are the primary compounds of Satureja species. Summer savory extract shows considerable biological potential in antioxidant, cytotoxic, and antibacterial assays. Regarding antioxidant activity, the summer savory extract is display an inhibitory concentration for lipid peroxidation. Summer savory has also Fe (III) reductive and free radical scavenging properties. Summer savory is also contained minerals and vitamins. . Sammer savory has important biological properties including antimicrobial activity, antioxidant activity, protection Jurkat T Cells, Alzheimer's disease, cancer, anti-infection, cardiovascular diseases, antidiabetic and anti-cholesterol effects. The leaves and stems of this plant are employed in the food, feed and pharmacological industries due to their antioxidant properties and substantial nutritional contents. Conclusively, summer savory is strongly recommended for human health due to its versatile properties and medicinal use.