AUTHOR=Dabbaghi Varnousfaderani Sara , Musazadeh Vali , Ghalichi Faezeh , Kavyani Zeynab , Razmjouei Soha , Faghfouri Amir Hossein , Ahrabi Sana Sedgh , Seyyed Shoura Seyyed Morteza , Dehghan Parvin 

TITLE=Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1191290

DOI=10.3389/fphar.2023.1191290

ISSN=1663-9812

ABSTRACT=<p><bold>Introduction:</bold> Although several meta-analyses support the positive effect of coenzyme Q10 (CoQ10) on biomarkers of oxidative stress and inflammation, the results of some other studies reject such effects.</p><p><bold>Methods:</bold> Therefore, in this umbrella meta-analysis, we performed a comprehensive systematic search in such databases as Web of Science, PubMed, Scopus, Embase, and Google Scholar up to January 2023.</p><p><bold>Results:</bold> Based on standardized mean difference analysis, CoQ10 supplementation significantly decreased serum C-reactive protein (CRP) (ES<sub>SMD</sub> = −0.39; 95% CI: 0.77, −0.01, <italic>p</italic> = 0.042) and malondialdehyde (MDA) (ES<sub>SMD</sub> = −1.17; 95% CI: 1.55, −0.79, <italic>p</italic> &lt; 0.001), while it increased the total antioxidant capacity (TAC) (ES<sub>SMD</sub> = 1.21; 95% CI: 0.61, 1.81, <italic>p</italic> &lt; 0.001) and serum superoxide dismutase (SOD) activity (ES<sub>SMD</sub> = 1.08; 95% CI: 0.37, 1.79, <italic>p</italic> = 0.003). However, CoQ10 supplementation had no significant reducing effect on tumor-necrosis factor-alpha (TNF- α) (ES<sub>SMD</sub> = −0.70; 95% CI: 2.09, 0.68, <italic>p</italic> = 0.320) and interleukin-6 (IL-6) levels (ES<sub>SMD</sub> = −0.85; 95% CI: 1.71, 0.01, <italic>p</italic> = 0.053). Based on weighted mean difference analysis, CoQ10 supplementation considerably decreased TNF-α (ES<sub>WMD</sub> = −0.46, 95% CI: 0.65, −0.27; <italic>p</italic> &lt; 0.001), IL-6 (ES<sub>WMD</sub> = −0.92, 95% CI: 1.40, −0.45; <italic>p</italic> &lt; 0.001), and CRP levels (effect sizes <sub>WMD</sub> = −0.28, 95% CI: 0.47, −0.09; <italic>p</italic> &lt; 0.001).</p><p><bold>Discussion:</bold> The results of our meta-analysis supported the alleviating effects of CoQ10 on markers of inflammation cautiously. However, CoQ10 had antioxidant effects regarding the improvement of all the studied antioxidant and oxidative stress biomarkers.</p><p><bold>Systematic Review Registration:</bold><ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323861" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323861</ext-link>, identifier CRD42022323861</p>