AUTHOR=Xie Jingjing , Li Zhiling , Jiang Yubao , Tang Dabin , Qiu Xia , Jia Ertao , Zhang Jianyong TITLE=Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1191158 DOI=10.3389/fphar.2023.1191158 ISSN=1663-9812 ABSTRACT=
Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued to progress; the patient responded well to baricitinib. This suggests that JAK/STAT signaling pathways play an essential role in the pathological process of POEMS syndrome.