AUTHOR=Li Rui , Craig Morgan , D'Argenio David Z. , Betts Alison , Mager Donald E. , Maurer Tristan S. TITLE=Editorial: Model-informed decision making in the preclinical stages of pharmaceutical research and development JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1184914 DOI=10.3389/fphar.2023.1184914 ISSN=1663-9812