AUTHOR=Fan Yujian , Yang Zhihua , Wang Lin , Liu Yangxi , Song Yulong , Liu Yu , Wang Xianliang , Zhao Zhiqiang , Mao Jingyuan TITLE=Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1154167 DOI=10.3389/fphar.2023.1154167 ISSN=1663-9812 ABSTRACT=

Heart failure with preserved ejection fraction accounts for a large proportion of heart failure, and it is closely related to a high hospitalization rate and high mortality rate of cardiovascular disease. Although the methods and means of modern medical treatment of HFpEF are becoming increasingly abundant, they still cannot fully meet the clinical needs of HFpEF patients. Traditional Chinese medicine is an important complementary strategy for the treatment of diseases in modern medicine, and it has been widely used in clinical research on HFpEF in recent years. This article reviews the current situation of HFpEF management, the evolution of guidelines, the clinical evidence and the mechanism of TCM in the treatment of HFpEF. The purpose of this study is to explore the application of TCM for HFpEF, to further improve the clinical symptoms and prognosis of patients and to provide a reference for the diagnosis and treatment of the disease.